L-Methylfolate: A promising therapy for treatment of depression

Major Depressive Disorder is an axis one diagnosis of mental illness, and the condition is chronic, necessitating the use of medicine for the span of one’s life. When struggling with depression, it can be incredibly challenging and frustrating to find the right medication. Depression is different for everyone, with the brain responding to a multitude of potential stimuli. If you have been agonizing over each new medication not working, there might be other factors to consider. L-Methyl folate is a supplement that can improve your body’s ability to process antidepressant medication more efficiently.

What is methylated folic acid?

Vitamins play a key role in the healthy functioning of the body and folate, B9, is no exception. It aids in the formation of red blood cells, cellular growth and division, protein metabolism, and it even prevents neural tube defects. Despite these important contributions to development, folate deficiency is a serious predicament faced by many individuals today. A lack of folate can result in anemia, but even worse, it can stimulate the development of Major Depressive Disorder and contribute to the ineffectiveness of antidepressant medication.

L-Methylfolate supplements are a promising solution to this problem. Because folate is found naturally in foods, you might wonder why you should take the methylated folic acid supplement instead. Folate has to be properly metabolized in order to be used by the body. Generally, because of the over processing of our foods, folic acid is used as a substitute, but it must go through four different conversion steps to become the correct “folate form” the body can successfully use in the cells. There are many contributing factors that can lead to an inability of the body to use folic acid, like alcoholism, pregnancy, medication interference and celiac disease, but regardless of the cause, a folate deficiency wreaks havoc on the body.

L-Methylfolate is the most bio-available form of folate that is easily absorbed by the body and readily utilized for normal functioning.

What does methylated folic acid do for depression?

L-Methylfolate supplements are currently the only known variant of folate with the ability to cross the blood-brain barrier, playing a role in the synthesis of  neurotransmitters. Understandably, this ability impacts the body’s synthesis of important neurochemicals, like serotonin, dopamine, and norepinephrine, which are the most important chemicals for regulating our mood. With an improved level of neurochemicals, the body is more capable of distributing and utilizing the effects of serotonin reuptake inhibitors as well as serotonin-norepinephrine reuptake inhibitors, the two most popular forms of antidepressants.

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